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Title: The Fusarium Graminearum Genome Reveals a Link Between Localized Polymorphism and Pathogen Specialization

Abstract

We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts.

Authors:
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Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
921228
Report Number(s):
PNNL-SA-57387
Journal ID: ISSN 0193-4511; SCEHDK; BM0102070; TRN: US200804%%1509
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Science, 317(5843):1400-1402
Additional Journal Information:
Journal Volume: 317; Journal Issue: 5843; Journal ID: ISSN 0193-4511
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; CEREALS; FUSARIUM; GENE MUTATIONS; GENES; PATHOGENS; RECOMBINATION; STRAINS; TELOMERES; fungi; genomics; Fusarium

Citation Formats

Cuomo, Christina A, Guldener, Ulrich, Xu, Jin Rong, Trail, Frances, Turgeon, Barbara G, Di Pietro, Antonio, Walton, Johnathan D, Ma, Li Jun, Baker, Scott E, Rep, Martijn, Adam, Gerhard, Antoniw, John, Baldwin, Thomas, Calvo, Sarah, Chang, Yueh Long, DeCaprio, David, Gale, Liane R, Gnerre, Sante, Goswami, Rubella S, Hammond-Kossack, Kim, Harris, Linda J, Hilburn, Karen, Kennell, John C, Kroken, Scott, Magnuson, Jon K, Mannhaupt, Gertrud, Mauceli, Evan, Mewes, Hans Werner, Mitterbauer, Rudolf, Muehlbauer, Gary, Munsterkotter, Martin, Nelson, David, O'Donnell, Kerry, Ouellet, Therese, Qi, Weihong, Quesneville, Hadi, Roncero, M Isabel, Seong, Kye Yong, Tetko, Igor V, Urban, Martin, Waalwijk, Cees, Ward, Todd J, Yao, Jiqiang, Birren, Bruce W, and Kistler, H Corby. The Fusarium Graminearum Genome Reveals a Link Between Localized Polymorphism and Pathogen Specialization. United States: N. p., 2007. Web. doi:10.1126/science.1143708.
Cuomo, Christina A, Guldener, Ulrich, Xu, Jin Rong, Trail, Frances, Turgeon, Barbara G, Di Pietro, Antonio, Walton, Johnathan D, Ma, Li Jun, Baker, Scott E, Rep, Martijn, Adam, Gerhard, Antoniw, John, Baldwin, Thomas, Calvo, Sarah, Chang, Yueh Long, DeCaprio, David, Gale, Liane R, Gnerre, Sante, Goswami, Rubella S, Hammond-Kossack, Kim, Harris, Linda J, Hilburn, Karen, Kennell, John C, Kroken, Scott, Magnuson, Jon K, Mannhaupt, Gertrud, Mauceli, Evan, Mewes, Hans Werner, Mitterbauer, Rudolf, Muehlbauer, Gary, Munsterkotter, Martin, Nelson, David, O'Donnell, Kerry, Ouellet, Therese, Qi, Weihong, Quesneville, Hadi, Roncero, M Isabel, Seong, Kye Yong, Tetko, Igor V, Urban, Martin, Waalwijk, Cees, Ward, Todd J, Yao, Jiqiang, Birren, Bruce W, & Kistler, H Corby. The Fusarium Graminearum Genome Reveals a Link Between Localized Polymorphism and Pathogen Specialization. United States. https://doi.org/10.1126/science.1143708
Cuomo, Christina A, Guldener, Ulrich, Xu, Jin Rong, Trail, Frances, Turgeon, Barbara G, Di Pietro, Antonio, Walton, Johnathan D, Ma, Li Jun, Baker, Scott E, Rep, Martijn, Adam, Gerhard, Antoniw, John, Baldwin, Thomas, Calvo, Sarah, Chang, Yueh Long, DeCaprio, David, Gale, Liane R, Gnerre, Sante, Goswami, Rubella S, Hammond-Kossack, Kim, Harris, Linda J, Hilburn, Karen, Kennell, John C, Kroken, Scott, Magnuson, Jon K, Mannhaupt, Gertrud, Mauceli, Evan, Mewes, Hans Werner, Mitterbauer, Rudolf, Muehlbauer, Gary, Munsterkotter, Martin, Nelson, David, O'Donnell, Kerry, Ouellet, Therese, Qi, Weihong, Quesneville, Hadi, Roncero, M Isabel, Seong, Kye Yong, Tetko, Igor V, Urban, Martin, Waalwijk, Cees, Ward, Todd J, Yao, Jiqiang, Birren, Bruce W, and Kistler, H Corby. 2007. "The Fusarium Graminearum Genome Reveals a Link Between Localized Polymorphism and Pathogen Specialization". United States. https://doi.org/10.1126/science.1143708.
@article{osti_921228,
title = {The Fusarium Graminearum Genome Reveals a Link Between Localized Polymorphism and Pathogen Specialization},
author = {Cuomo, Christina A and Guldener, Ulrich and Xu, Jin Rong and Trail, Frances and Turgeon, Barbara G and Di Pietro, Antonio and Walton, Johnathan D and Ma, Li Jun and Baker, Scott E and Rep, Martijn and Adam, Gerhard and Antoniw, John and Baldwin, Thomas and Calvo, Sarah and Chang, Yueh Long and DeCaprio, David and Gale, Liane R and Gnerre, Sante and Goswami, Rubella S and Hammond-Kossack, Kim and Harris, Linda J and Hilburn, Karen and Kennell, John C and Kroken, Scott and Magnuson, Jon K and Mannhaupt, Gertrud and Mauceli, Evan and Mewes, Hans Werner and Mitterbauer, Rudolf and Muehlbauer, Gary and Munsterkotter, Martin and Nelson, David and O'Donnell, Kerry and Ouellet, Therese and Qi, Weihong and Quesneville, Hadi and Roncero, M Isabel and Seong, Kye Yong and Tetko, Igor V and Urban, Martin and Waalwijk, Cees and Ward, Todd J and Yao, Jiqiang and Birren, Bruce W and Kistler, H Corby},
abstractNote = {We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts.},
doi = {10.1126/science.1143708},
url = {https://www.osti.gov/biblio/921228}, journal = {Science, 317(5843):1400-1402},
issn = {0193-4511},
number = 5843,
volume = 317,
place = {United States},
year = {Fri Sep 07 00:00:00 EDT 2007},
month = {Fri Sep 07 00:00:00 EDT 2007}
}