AN IMPROVED METHOD FOR THE BIOLOGICAL MONITORING OF VOLATILE COMPOUNDS
Exposure assessment is a critical component in estimating health risk. The analysis of exhaled breath offers an ideal non-invasive matrix for measuring volatile biomarkers associated with the absorption, distribution, metabolism and elimination of chemicals under a variety of environmental conditions. A real-time, field-portable system was developed to directly analyze undiluted exhaled air from experimental animals and humans. The exhaled breath data is evaluated using a physiologically based pharmacokinetic model to estimate total exposure, internal target tissue dosimetry, and to describe kinetic changes. To date, the system has been used to conduct occupational exposure assessments and dermal bioavailability studies.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 920554
- Report Number(s):
- PNNL-SA-54353; TRN: US200818%%628
- Resource Relation:
- Conference: Environmental Health in Central and Eastern Europe, 65-71
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
VOLATILE MATTER
HEALTH HAZARDS
BIOLOGICAL INDICATORS
EXHALATION
BREATH
PORTABLE EQUIPMENT
MEASURING INSTRUMENTS
OCCUPATIONAL EXPOSURE
MONITORING
dermal bioavailability
occupational exposure assessment
exhaled breath
PBPK.