An Iron Catalyst for Ketone Hydrogenations Under Mild Conditions

Journal Article · Mon Oct 01 00:00:00 EDT 2007 · Angewandte Chemie International Edition, 46(39):7360-7363

DOI:https://doi.org/10.1002/anie.200703053· OSTI ID:920201

Bullock, R Morris

Casey and Guan reported a homogeneous catalyst for ketone hydrogenation that does not require a precious metal, but instead is based on iron. Excellent yields and chemoselectivity for hydrogenation are found under mild conditions (25 °C, 3 atm H2). An ionic hydrogenation mechanism allows the delivery of a proton from the OH and a hydride from the metal. RMB gratefully acknowledges funding from the Division of Chemical Sciences, Office of Basic Energy Sciences, US Department of Energy, and from a grant from the Laboratory Directed Research and Development Program. Pacific Northwest National Laboratory is operated by Battelle for the U.S. Department of Energy.

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 920201
• Report Number(s): PNNL-SA-56110; KC0302010; TRN: US0805667
• Journal Information: Angewandte Chemie International Edition, 46(39):7360-7363, Vol. 46, Issue 39
• Country of Publication: United States
• Language: English

Related Subjects

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS
CATALYSTS
HYDRIDES
HYDROGENATION
IRON
KETONES
PROTONS
homogeneous catalysis
iron
hydrogenation
hydride
proton transfer