Hospital For Special Surgery/Immune System REgulation In Musculoskeletal Disorders
Inflammation on musculoskeletal disorders such as rheumatoid arthritis (RA) is the result of dysregulation of the immune system. When the immune system, which maintains the integrity of the organism in an environment rich in infectious microbes, becomes misdirected toward components of one’s own tissue, autoimmune disease can result with autoantibodies contributing to the inflammation and tissue damage. RA is a chronic autoimmune disease marked by severe inflammation that causes pain, swelling, stiffness and loss of function in the joints, which is estimated to affect 1 percent of the US adult population. Furthermore, autoimmune diseases, which affect women at a higher rate, are the fourth largest cause of disability among women in the US and among the top ten causes of death. The long range goal of this study is to elucidate the mechanisms that regulate the generation of autoantibodies by B cells in normal individuals and in patients with autoimmune diseases and provide insights into potential therapeutic interventions.
- Research Organization:
- Hospital For Special Surgery
- Sponsoring Organization:
- USDOE - Office of Environment, Safety and Health (EH)
- DOE Contract Number:
- FG02-05ER64102
- OSTI ID:
- 912820
- Report Number(s):
- 1
- Country of Publication:
- United States
- Language:
- English
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