Hematopoietic stem cell compartment: Acute and late effects of radiation therapy an chemotherapy
- Harvard Medical School, Boston, MA (United States)
- Univ. of Rochester Medical School, NY (United States)
- Univ. of Pittsburgh Medical Center, PA (United States); and others
The bone marrow is an important dose-limiting cell renewal tissue for chemotherapy, wide-field irradiation, and autologous bone marrow transplantion. Over the past 5-10 years a great deal has been discovered about the hematopoietic stem cell compartment. Although the toxicity associated with prolonged myelosuppression continue to limit the wider use of chemotherapy and irradiation, ways are being discovered to circumvent this toxicity such as with the increasing use of cytokines. This review describes what is known of how chemotherapy and irradiation damage stem cells and the microenvironment, how cytokines protect hematopoietic cells from radiation damage and speed marrow recovery after chemotherapy or marrow transplantation, and how various types of blood marrow cells contribute to engraftment and long-term hematopoiesis after high doses of cytotoxic agents and/or total body irradiation. 167 refs., 7 figs., 6 tabs.
- OSTI ID:
- 90892
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Vol. 31, Issue 5; Other Information: PBD: 30 Mar 1995
- Country of Publication:
- United States
- Language:
- English
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