CrAsH: A Biarsenical Multi-use Affinity Probe with low non-specific fluorescence
Journal Article
·
· Chemical Communications
A biarsenical fluorescent probe 5-carboxy-4?,5?-bis(1,3,2-dithioarsolan-2-yl)fluorescein (CrAsH) was conveniently synthesized from 5-carboxyfluorescein. This probe shows highly selective binding to tetracysteine tags and low hydrophobic non-specific binding in vitro. It provides a potential application for protein labeling and cell imaging.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 885464
- Report Number(s):
- PNNL-SA-48401; 7195; 7195b; 7195c; KP1102010; TRN: US200616%%653
- Journal Information:
- Chemical Communications, Vol. 24
- Country of Publication:
- United States
- Language:
- English
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