A genome-wide screen identifies a single Β-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins
Journal Article
·
· BMC Genomics
OSTI ID:842807
Defensins comprise a large family of cationic antimicrobial peptides that are characterized by the presence of a conserved cysteine-rich defensin motif. Based on the spacing pattern of cysteines, these defensins are broadly divided into five groups, namely plant, invertebrate, {alpha}-, {beta}-, and {theta}-defensins, with the last three groups being mostly found in mammalian species. However, the evolutionary relationships among these five groups of defensins remain controversial.
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC03-76SF00098
- OSTI ID:
- 842807
- Report Number(s):
- LBNL-58136; R&D Project: GHPG1A; TRN: US200516%%965
- Journal Information:
- BMC Genomics, Vol. 5, Issue 56; Other Information: Journal Publication Date: 08/13/2004
- Country of Publication:
- United States
- Language:
- English
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