Types of variation in the cell population are similar to those in the populations of organisms. Developmental biology of cardiac myocytes
We review the studies of polyploidy in the heart muscle and changes in the abundance of myocytes during ontogenesis. Variation in the number and ploidy of muscle cells has been observed in the normal heart muscle. The types of genomic variation are similar to populational variations of organisms, i.e., hereditary and modificational variation. In studies of changes of the myocyte genome, we have found that growth of the heart has some additional reserve capacity, which may be realized under abnormal conditions when the heart muscle undergoes hypertrophy. This additional reserve capacity depends on the level of polyploidy in the cells of the heart muscle which is established during early postnatal embryogenesis. 30 refs., 10 figs.
- OSTI ID:
- 83473
- Journal Information:
- Russian Journal of Developmental Biology, Vol. 25, Issue 5; Other Information: PBD: Sep-Oct 1994; TN: Translated from Ontogenez; 25: No. 5, 29-43(Sep-Oct 1994)
- Country of Publication:
- United States
- Language:
- English
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