Final Report: Bone Mass Inheritance: A Project to Identify the Genetic Regulation of Bone Mass

Title: Final Report: Bone Mass Inheritance: A Project to Identify the Genetic Regulation of Bone Mass

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Abstract

This project was designed to find human chromosomal locations that contain genes regulating peak bone density. It is part of a whole genome search for those loci,each responsible for at least 15% of the variation in the peak adult bone density. We accomplished this with a sib pair design, combined with simultaneous examination of extended kindreds. This project gave partial support of the recruitment which has now been completed. The project will extend into 2003. During the remainder of the project, a whole genome scan will be performed from the entire cohort of 2226 persons who have DNA archived, followed by linkage analysis. This project will meet the scientific objective leading eventually to expanded options for treating the condition that leads to bone thinning osteoporosis, and potential fractures in aging populations.

Authors:: Recker, Robert R., M.D.

Publication Date:: Thu Mar 28 00:00:00 EST 2002

Research Org.:: Creighton University (US)

Sponsoring Org.:: USDOE Office of Energy Research (ER) (US)

OSTI Identifier:: 793992

DOE Contract Number:: FG03-00ER63000

Resource Type:: Technical Report

Resource Relation:: Other Information: PBD: 28 Mar 2002

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; ADULTS; AGING; DESIGN; DNA; FRACTURES; GENES; GENETICS; OSTEOPOROSIS; REGULATIONS; OSTEOPOROIS: GENETICS; SIB-PAIRS

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                    Recker, Robert R., M.D. Final Report: Bone Mass Inheritance: A Project to Identify the Genetic Regulation of Bone Mass.  United States: N. p., 2002. 
        Web.

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                    Recker, Robert R., M.D. Final Report: Bone Mass Inheritance: A Project to Identify the Genetic Regulation of Bone Mass.  United States.

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                    Recker, Robert R., M.D. 2002.  
        "Final Report: Bone Mass Inheritance: A Project to Identify the Genetic Regulation of Bone Mass".  United States.

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@article{osti_793992,

  title        = {Final Report: Bone Mass Inheritance: A Project to Identify the Genetic Regulation of Bone Mass},

  author       = {Recker, Robert R., M.D.},

  abstractNote = {This project was designed to find human chromosomal locations that contain genes regulating peak bone density. It is part of a whole genome search for those loci,each responsible for at least 15% of the variation in the peak adult bone density. We accomplished this with a sib pair design, combined with simultaneous examination of extended kindreds. This project gave partial support of the recruitment which has now been completed. The project will extend into 2003. During the remainder of the project, a whole genome scan will be performed from the entire cohort of 2226 persons who have DNA archived, followed by linkage analysis. This project will meet the scientific objective leading eventually to expanded options for treating the condition that leads to bone thinning osteoporosis, and potential fractures in aging populations.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/793992},
  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Thu Mar 28 00:00:00 EST 2002},

  month        = {Thu Mar 28 00:00:00 EST 2002}

}

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