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Title: AUTOMATION FOR THE SYNTHESIS AND APPLICATION OF PET RADIOPHARMACEUTICALS.

AUTOMATION FOR THE SYNTHESIS AND APPLICATION OF PET RADIOPHARMACEUTICALS. The development of automated systems supporting the production and application of PET radiopharmaceuticals has been an important focus of researchers since the first successes of using carbon-11 (Comar et al., 1979) and fluorine-18 (Reivich et al., 1979) labeled compounds to visualize functional activity of the human brain. These initial successes of imaging the human brain soon led to applications in the human heart (Schelbert et al., 1980), and quickly radiochemists began to see the importance of automation to support PET studies in humans (Lambrecht, 1982; Langstrom et al., 1983). Driven by the necessity of controlling processes emanating high fluxes of 511 KeV photons, and by the tedium of repetitive syntheses for carrying out these human PET investigations, academic and government scientists have designed, developed and tested many useful and novel automated systems in the past twenty years. These systems, originally designed primarily by radiochemists, not only carry out effectively the tasks they were designed for, but also demonstrate significant engineering innovation in the field of laboratory automation.
Authors:
Publication Date:
OSTI Identifier:787833
Report Number(s):BNL--68614; KP140103
R&D Project: CO11; KP140103; TRN: US0110565
DOE Contract Number:AC02-98CH10886
Resource Type:Book
Data Type:
Resource Relation:Other Information: BOOK: HANDBOOK OF RADIOPHARMACEUTICLES:RADIOCHEMISTRY AND APPLICATIONS,EDITED BY WELCH,M.J.; REDVANLY,C.; JOHN WILEY AND SONS, LTD., UNITED KINGDOM; PBD: 21 Sep 2001
Research Org:Brookhaven National Lab., Upton, NY (US)
Sponsoring Org:USDOE Office of Energy Research (ER) (US)
Country of Publication:United States
Language:English
Subject: 62 RADIOLOGY AND NUCLEAR MEDICINE; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; AUTOMATION; BRAIN; CARBON 11; FLUORINE 18; RADIOPHARMACEUTICALS; SYNTHESIS; POSITRON COMPUTED TOMOGRAPHY