Nucleotide sequence of a novel HLA-DRB1 allele, DRB1*0806
- Univ. of Elm (Germany)
Human major histocompatibility complex (HLA) class II genes are organized in three subregions, DR, DQ, and DP. The genes in this region are extremely polymorphic and new alleles are continuously being identified. We report here a novel allele that was found by the amplification and direct sequencing of exon 2 of DRB1. The novel allele was found in a bone marrow transplantation patient, the mother, and two serologically identified donors. The patient was typed as DR3/DR8, the mother as DR2/DR8, and the father as DR3/DR8 heterozygote. Therefore, the patient inherited the DR3 haplotype from the father and the DR8 haplotype from the mother. At first, it was not possible to definitely determine the subtype of the DR8 allele by oligotyping. 4 refs., 1 fig.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 75578
- Journal Information:
- Immunogenetics, Vol. 41, Issue 1; Other Information: PBD: Jan 1995
- Country of Publication:
- United States
- Language:
- English
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