Model of iodine metabolism in a T₃-thyrotoxic patient undergoing I-131 therapy

Technical Report · Sun Jun 01 00:00:00 EDT 1975

DOI:https://doi.org/10.2172/7363203· OSTI ID:7363203

Ahuja, S.; Price, R.; Brill, A. B.; Dobyns, B. M.; Berman, M.

Data on radioactivity in the thyroid, urine, serum, butanol-extractable iodine (BEI) and chromatographic fractionations of BEI, obtained during four I-131 therapeutic treatments of a T₃-thyrotoxic patient, have been analyzed and simulated with the help of a 7-compartment model. Good fits to most of the data can be obtained with both the dose-independent and dose-dependent models. A model with 3 or 4 compartments, which provides adequate fits to iodine kinetic data in most euthyroid and hyperthyroid patients is not satisfactory in the case of this patient. Thus, to represent iodine metabolism during T₃-thyrotoxicosis therapy, we find that it is necessary to provide for separate biochemical pathways for the BEI components as well as the butanol-insoluble compounds released by the thyroid gland. (auth)

• Research Organization: Vanderbilt Univ., Nashville, Tenn. (United States). Div. of Nuclear Medicine and Biophysics; Cleveland Metropolitan General Hospital, Ohio (United States); National Cancer Inst., Bethesda, Md. (United States). Lab. of Theoretical Biology
• Sponsoring Organization: US Energy Research and Development Administration (ERDA)
• OSTI ID: 7363203
• Report Number(s): ORO-2401-95; TRN: 76-015164
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HYPERTHYROIDISM
RADIOTHERAPY
IODINE 131
BIOLOGICAL RADIATION EFFECTS
RADIONUCLIDE ADMINISTRATION
PATIENTS
INTERNAL IRRADIATION
TISSUE DISTRIBUTION
BIOLOGICAL MODELS
METABOLISM
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
DAYS LIVING RADIOISOTOPES
DISEASES
DISTRIBUTION
ENDOCRINE DISEASES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
IRRADIATION
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
THERAPY
560161* - Radionuclide Effects
Kinetics
& Toxicology- Man