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Title: Prevalence of symptoms of systemic lupus erythematosus (SLE) and of fluorescent antinuclear antibodies associated with chronic exposure to trichloroethylene and other chemicals in well water

Abstract

Criteria for the recognition of systemic lupus erythematosus (SLE) were applied to 362 subjects exposed to trichloroethylene, trichloroethane, inorganic chromium, and other chemicals in water obtained from wells in an industrially contaminated aquifer in Tucson, Arizona. Their antinuclear autoantibodies were measured by fluorescence (FANA) in serum. Ten patients with clinical SLE and/or other collagen-vascular diseases were considered separately. Results were compared to an Arizona control group, to published series, and to laboratory controls. Frequencies of each of 10 ARA symptoms were higher in exposed subjects than in any comparison group except those with clinical SLE. The number of subjects with 4 or more symptoms was 2.3 times higher compared to referent women and men. FANA titers > 1:80 was approximately 2.3 times higher in women but equally frequent in men as in laboratory controls. ARA score and FANA rank were correlated with a coefficient (cc) of .1251, r{sup 2} = .0205 in women and this correlation was almost statistically significant in men cc = .1282, r{sup 2} = .0253. In control men and women neither correlation was significant. Long-term low-dose exposure to TCE and other chemicals in contaminated well water significantly increased symptoms of lupus erthematosus as perceived by themore » ARA score and the increased FANA titers.« less

Authors:
;  [1]
  1. Univ. of Southern California, Los Angeles (United States)
Publication Date:
OSTI Identifier:
7279437
Resource Type:
Journal Article
Journal Name:
Environmental Research; (United States)
Additional Journal Information:
Journal Volume: 57:1; Journal ID: ISSN 0013-9351
Country of Publication:
United States
Language:
English
Subject:
54 ENVIRONMENTAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ARIZONA; WATER POLLUTION; CHLORINATED ALIPHATIC HYDROCARBONS; TOXICITY; CHROMIUM; LUPUS; EPIDEMIOLOGY; WATER WELLS; CONTAMINATION; ANTIBODIES; CHRONIC EXPOSURE; FLUORESCENCE; MAN; SYMPTOMS; VASCULAR DISEASES; ANIMALS; DEVELOPED COUNTRIES; DISEASES; ELEMENTS; FEDERAL REGION IX; HALOGENATED ALIPHATIC HYDROCARBONS; IMMUNE SYSTEM DISEASES; LUMINESCENCE; MAMMALS; METALS; NORTH AMERICA; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; POLLUTION; PRIMATES; TRANSITION ELEMENTS; USA; VERTEBRATES; WELLS; 540320* - Environment, Aquatic- Chemicals Monitoring & Transport- (1990-); 560300 - Chemicals Metabolism & Toxicology

Citation Formats

Kilburn, K H, and Warshaw, R H. Prevalence of symptoms of systemic lupus erythematosus (SLE) and of fluorescent antinuclear antibodies associated with chronic exposure to trichloroethylene and other chemicals in well water. United States: N. p., 1992. Web. doi:10.1016/S0013-9351(05)80014-3.
Kilburn, K H, & Warshaw, R H. Prevalence of symptoms of systemic lupus erythematosus (SLE) and of fluorescent antinuclear antibodies associated with chronic exposure to trichloroethylene and other chemicals in well water. United States. https://doi.org/10.1016/S0013-9351(05)80014-3
Kilburn, K H, and Warshaw, R H. 1992. "Prevalence of symptoms of systemic lupus erythematosus (SLE) and of fluorescent antinuclear antibodies associated with chronic exposure to trichloroethylene and other chemicals in well water". United States. https://doi.org/10.1016/S0013-9351(05)80014-3.
@article{osti_7279437,
title = {Prevalence of symptoms of systemic lupus erythematosus (SLE) and of fluorescent antinuclear antibodies associated with chronic exposure to trichloroethylene and other chemicals in well water},
author = {Kilburn, K H and Warshaw, R H},
abstractNote = {Criteria for the recognition of systemic lupus erythematosus (SLE) were applied to 362 subjects exposed to trichloroethylene, trichloroethane, inorganic chromium, and other chemicals in water obtained from wells in an industrially contaminated aquifer in Tucson, Arizona. Their antinuclear autoantibodies were measured by fluorescence (FANA) in serum. Ten patients with clinical SLE and/or other collagen-vascular diseases were considered separately. Results were compared to an Arizona control group, to published series, and to laboratory controls. Frequencies of each of 10 ARA symptoms were higher in exposed subjects than in any comparison group except those with clinical SLE. The number of subjects with 4 or more symptoms was 2.3 times higher compared to referent women and men. FANA titers > 1:80 was approximately 2.3 times higher in women but equally frequent in men as in laboratory controls. ARA score and FANA rank were correlated with a coefficient (cc) of .1251, r{sup 2} = .0205 in women and this correlation was almost statistically significant in men cc = .1282, r{sup 2} = .0253. In control men and women neither correlation was significant. Long-term low-dose exposure to TCE and other chemicals in contaminated well water significantly increased symptoms of lupus erthematosus as perceived by the ARA score and the increased FANA titers.},
doi = {10.1016/S0013-9351(05)80014-3},
url = {https://www.osti.gov/biblio/7279437}, journal = {Environmental Research; (United States)},
issn = {0013-9351},
number = ,
volume = 57:1,
place = {United States},
year = {Sat Feb 01 00:00:00 EST 1992},
month = {Sat Feb 01 00:00:00 EST 1992}
}