Increased contraction frequency in rat uterine strips treated in vitro with o,p prime -DDT

Journal Article · Wed May 01 00:00:00 EDT 1991 · Bulletin of Environmental Contamination and Toxicology; (United States)

DOI:https://doi.org/10.1007/BF01689963· OSTI ID:7278802

Juberg, D R; Loch-Caruso, R ^[1]

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1. Univ. of Michigan, Ann Arbor (United States)

Elevated levels of DDT and other organochlorine pesticides have been associated with spontaneous abortion and preterm birth in several species, including humans. Despite the prevalence of organochlorine pesticides in the environment, a mechanistic basis for this association has not been explored. Furthermore, while DDT has been associated with inhibition of calcium ATPases, altered gap junctional communication and electrophysiological changes, all of which could affect the excitation-contraction process characteristic of smooth muscle, direct effects of DDT on uterine smooth muscle have not been reported. This study was initiated to assess the direct effects of o,p{prime}-DDT (an estrogenic isomer present in the technical grade preparation) on pregnant rat uterine tissue.

• OSTI ID: 7278802
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (United States), Vol. 46:5; ISSN 0007-4861
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MUSCLES
PHYSIOLOGY
ORGANIC CHLORINE COMPOUNDS
BIOLOGICAL EFFECTS
ABORTION
DDT
INSECTICIDES
PREGNANCY
RATS
REPRODUCTION
ANIMALS
AROMATICS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PESTICIDES
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology