Comparative toxicity and structure-activity in Chlorella and Tetrahymena: Monosubstituted phenols

Journal Article · Mon Jul 01 00:00:00 EDT 1991 · Bulletin of Environmental Contamination and Toxicology; (United States)

DOI:https://doi.org/10.1007/BF01689453· OSTI ID:7278789

Jaworska, J S; Schultz, T W ^[1]

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1. Univ. of Tennessee, Knoxville (United States)

The relative toxicity of selected monosubstituted phenols has been assessed by Kramer and Truemper in the Chlorella vulgaris assay. The authors examined population growth inhibition of this simple green algae under short-term static conditions for 33 derivatives. However, efforts to develop a strong predictive quantitative structure-activity relationship (QSAR) met with limited success because they modeled across modes of toxic action or segregated derivatives such as positional isomers (i.e., ortho-, meta-, para-). In an effort to further their understanding of the relationships of ecotoxic effects of phenols, the authors have evaluated the same derivatives reported by Kramer and Truemper in the Tetrahymena pyriformis population growth assay, compared the responses in both systems and developed QSARs for the Chlorella vulgaris data based on mechanisms of action.

• OSTI ID: 7278789
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (United States), Vol. 47:1; ISSN 0007-4861
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHLORELLA
POPULATION DYNAMICS
PHENOLS
STRUCTURE-ACTIVITY RELATIONSHIPS
TETRAHYMENA
ISOMERS
TOXICITY
ALGAE
ANIMALS
AROMATICS
CHLOROPHYCOTA
CILIATA
HYDROXY COMPOUNDS
INVERTEBRATES
MICROORGANISMS
ORGANIC COMPOUNDS
PLANTS
PROTOZOA
UNICELLULAR ALGAE
560300* - Chemicals Metabolism & Toxicology