Diminution in phase 1 and phase 2 drug metabolizing enzymes of rat lung by asbestos: An in vitro study

Journal Article · Fri Nov 01 00:00:00 EST 1991 · Bulletin of Environmental Contamination and Toxicology; (United States)

DOI:https://doi.org/10.1007/BF01701131· OSTI ID:7278736

Khan, S G; Ali, S; Rahman, Q ^[1]

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1. Industrial Toxicology Research Centre, Lucknow (India)

In the present paper studies are presented concerning the effect of three varieties of asbestos namely, chrysotile, crocidolite and amosite, and of titanium dioxide, an inert non-asbestos dust, on the enzymes of phase 1 and phase 2 drug metabolism in isolated rat lung microsomes and post-microsomal fraction. Since 3-methylcholanthrene (3-MC) is known to induce cytochromes P-450 in the IA family and their associated activity, benzo(a)pyrene hydroxylase, therefore, the effect of these mineral fibers on cytochrome P-450 and benzo(a)pyrene hydroxylase in lung microsomes isolated from 3-MC-treated rats was studied.

• OSTI ID: 7278736
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (United States), Vol. 47:5; ISSN 0007-4861
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ASBESTOS
BIOLOGICAL EFFECTS
MIXED-FUNCTION OXIDASES
ENZYME ACTIVITY
LUNGS
MICROSOMES
RATS
ANIMALS
BODY
CELL CONSTITUENTS
ENZYMES
MAMMALS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGENASES
PROTEINS
RESPIRATORY SYSTEM
RIBOSOMES
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology