beta. -Receptor-mediated increase in cerebral blood flow during hypoglycemia

Journal Article · Thu Oct 01 00:00:00 EDT 1987 · American Journal of Physiology; (USA)

OSTI ID:7266620

Hollinger, B R; Bryan, R M ^[1]

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1. Pennsylvania State Univ., Hershey (USA)

The authors tested the hypothesis that {beta}-adrenergic receptor stimulation is involved with the increase in regional cerebral blood flow (rCBF) during hypoglycemia. Rats were surgically prepared with the use of halothane-nitrous oxide anesthesia. A plaster restraining cast was placed around the hindquarters, and anesthesia was discontinued. Hypoglycemia was produced by an intravenous injection of insulin; normoglycemic control rates were given saline. Propranolol was administered to some control and some hypoglycemic rats to block the {beta}-adrenergic receptors. Regional CBF was measured using 4-(N-methyl-{sup 14}C)iodoantipyrine. Regional CBF increased during hypoglycemia in rats that were not treated with propranolol. The increase varied from {approximately}60 to 200% depending on the brain region. During hypoglycemia, propranolol abolished the increase in rCBF in the hypothalamus, cerebellum, and pyramidal tract. In other regions the increase in rCBF was only 33-65% of the increase in hypoglycemic rats that were not treated with propranolol. They conclude that {beta}-receptor stimulation plays a major role in the increase in rCBF during hypoglycemia.

• OSTI ID: 7266620
• Journal Information: American Journal of Physiology; (USA), Vol. 253:4; ISSN 0002-9513
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL STRESS
BIOLOGICAL EFFECTS
BLOOD FLOW
RADIOASSAY
ANTIPYRINE
CARBON 14 COMPOUNDS
CEREBRUM
INSULIN
METABOLIC DISEASES
RATS
RECEPTORS
ANIMALS
ANTIPYRETICS
AZOLES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DISEASES
DRUGS
HETEROCYCLIC COMPOUNDS
HORMONES
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDE HORMONES
PROTEINS
PYRAZOLES
PYRAZOLINES
RODENTS
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques