The synthesis of 2-nitro-1-((2-hydroxyethoxy)methyl)imidazole (azomycin acyclonucleoside)
- Oak Ridge National Lab., TN (United States)
Synthesis of acyclonucleosides as analogues of naturally occurring ribonucleosides has been the subject of major research investigations since the advent of the chemotherapeutic agent acyclovir (Zovirax), an acyclic analogue of guanosine. The intensity of research interest in this area is obvious from the fact that almost every conceivable acyclic analogue of naturally occurring or biologically active synthetic nucleosides have been prepared during the past decade. The synthesis of 2-nitro-1-((2-hydroxyethoxy)methyl)imidazole, the acyclonucleoside analogue of antibiotic azomycin (azomycin acyclonucleoside), is accomplished via alkylation of azomycin with 2-benzoyloxyethoxymethylene chloride followed by debenzoylation.
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 7263218
- Journal Information:
- Nucleosides and Nucleotides; (United States), Vol. 9:7; ISSN 0732-8311
- Country of Publication:
- United States
- Language:
- English
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