Variant translocations (9; 11): Identification of the critical genetic rearrangement
- Univ. of Chicago, IL (United States)
- Children's Memorial Hospital, Chicago, IL (United States)
The t(9;11)(p22;q23) is a recurring abnormality in acute nonlymphocytic leukemia. The analysis of complex 9;11 translocations will aid in the identification of the conserved chromosomal junction or the critical genetic alteration created by the rearrangement; however, variant translocations involving chromosomes {number sign}9 and {number sign}11 have not been reported. The authors have identified such variants in two patients who had acute myelomonocytic leukemia and acute monocytic leukemia, characterized by a t(9;11;18)(p22;q23;q12) and a t(9;11;13)(p22;q23;q34), respectively. The conserved junction resulting from these rearrangements is created by the translation of chromosomal material from 9p to 11q.
- DOE Contract Number:
- FG02-86ER60408
- OSTI ID:
- 7262953
- Journal Information:
- Cancer Genetics and Cytogenetics; (United States), Vol. 30; ISSN 0165-4608
- Country of Publication:
- United States
- Language:
- English
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