Toxicological dose assessment and acute health effect criteria
The use of hazardous materials requires the means of assessing doses from postulated accidental exposures to the hazardous materials. Hazardous materials include radiological and toxicological substances. Health effects are often divided into either acute (short term exposure) or chronic (long-term-exposure)-categories. Dose assessments and health effects are used in Hazard Classification, Safety Analysis Reports and Unreviewed Safety Question Determinations. The use of hazardous substances requires a means of assessing the potential health effects from exposure. Two types of toxicological data exist. The first is measured effects from human exposure, either accidentally or studies. The second consists of data from toxicity and lethality studies on mammals, often mice or rats. Because the data for human exposure is severely limited, an approach is needed that uses basic toxicity and lethality data from animal studies to estimate acute health effects in humans. The approach chosen is the one suggested jointly by the EPA, FEMA, and DOT in their Technical Guidance for Hazards Analysis'', December 1987.
- Research Organization:
- EG and G Rocky Flats, Inc., Golden, CO (United States). Rocky Flats Plant
- Sponsoring Organization:
- USDOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- AC34-90DP62349
- OSTI ID:
- 7260139
- Report Number(s):
- RFP-4588; CONF-9208117-5; ON: DE92019362
- Resource Relation:
- Conference: 1992 safety analysis workshop, Salt Lake City, UT (United States), 11-13 Aug 1992
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS
HAZARDOUS MATERIALS
RISK ASSESSMENT
DOSES
HEALTH HAZARDS
ROCKY FLATS PLANT
HAZARDS
MATERIALS
NATIONAL ORGANIZATIONS
US AEC
US DOE
US ERDA
US ORGANIZATIONS
560300* - Chemicals Metabolism & Toxicology
054000 - Nuclear Fuels- Health & Safety