Dopamine D sub 2 receptors in the cerebral cortex: Distribution and pharmacological characterization with ( sup 3 H)raclopride

Journal Article · Tue Aug 01 00:00:00 EDT 1989 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.86.16.6412· OSTI ID:7244609

Lidow, M S; Goldman-Rakic, P S; Rakic, P; Innis, R B ^[1]

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1. Yale Univ., New Haven, CT (USA)

An apparent involvement of dopamine in the regulation of cognitive functions and the recognition of a widespread dopaminergic innervation of the cortex have focused attention on the identity of cortical dopamine receptors. However, only the presence and distribution of dopamine D{sub 1} receptors in the cortex have been well documented. Comparable information on cortical D{sub 2} sites is lacking. The authors report here the results of binding studied in the cortex and neostriatum of rat and monkey using the D{sub 2} selective antagonist ({sup 3}H)raclopride. In both structures ({sup 3}H)raclopride bound in a sodium-dependent and saturable manner to a single population of sites with pharmacological profiles of dopamine D{sub 2} receptors. D{sub 2} sites were present in all regions of the cortex, although their density was much lower than in the neostriatum. The density of these sites in both monkey and, to a lesser extent, rat cortex displayed a rostral-caudal gradient with highest concentrations in the prefrontal and lowest concentrations in the occipital cortex, corresponding to dopamine levels in these areas. Thus, the present study established the presence and widespread distribution of dopamine D{sub 2} receptors in the cortex.

• OSTI ID: 7244609
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 86:16; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DOPAMINE
RECEPTORS
SYMPATHOMIMETICS
CROSS-LINKING
TRITIUM COMPOUNDS
TISSUE DISTRIBUTION
CALCIUM COMPOUNDS
CATIONS
CEREBRUM
DOSE-RESPONSE RELATIONSHIPS
MAGNESIUM COMPOUNDS
MONKEYS
PHARMACOLOGY
RATS
SODIUM COMPOUNDS
TEMPERATURE DEPENDENCE
ALKALI METAL COMPOUNDS
ALKALINE EARTH METAL COMPOUNDS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CHARGED PARTICLES
CHEMICAL REACTIONS
DISTRIBUTION
DRUGS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
IONS
MAMMALS
MEMBRANE PROTEINS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYMERIZATION
POLYPHENOLS
PRIMATES
PROTEINS
RODENTS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques