Pathways for formation of catechol and 1,2,4-benzenetriol in rabbits

Journal Article · Tue Aug 01 00:00:00 EDT 1989 · Bulletin of Environmental Contamination and Toxicology; (USA)

DOI:https://doi.org/10.1007/BF01701751· OSTI ID:7244249

Inoue, Osamu; Seiji, Kazunori ^[1]; Ikeda, Masayuki ^[2]

---

1. Tohoku Rosai Hospital, Sendai (Japan) Tohoku Univ. School of Medicine, Sendai (Japan)
2. Tohoku Univ. School of Medicine, Sendai (Japan)

Benzene, an established human leukemogen, was once widely used as an industrial solvent and is currently an important material for organic synthesis. Its metabolism in man and animals has also been studied extensively, and phenolic compounds were identified as major metabolites in urine after benzene exposure. One point yet to be elucidated is the pathway for formation of catechol (or 1,2-benzenediol). Early studies suggested that catechol will be formed via phenol whereas a later study failed to identify catechol in the urine of men and rabbits after oral administration methods of {sup 14}C-phenol. Sensitive HPLC methods have been recently developed in our laboratory to measure urinary phenolic metabolites and t,t-muconic acid. The methods were applied to show that phenol is not a precursor of catechol in rabbits. Evidence is also presented that 1,2,4-benzenetriol is formed only from quinol (1,4-benzenediol) and not from catechol.

• OSTI ID: 7244249
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (USA), Vol. 43:2; ISSN 0007-4861
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZENE
METABOLISM
PYROCATECHOL
BIOLOGICAL PATHWAYS
METABOLITES
PHENOLS
RABBITS
URINE
ANIMALS
AROMATICS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
DEVELOPERS
HYDROCARBONS
HYDROXY COMPOUNDS
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
POLYPHENOLS
VERTEBRATES
WASTES
560300* - Chemicals Metabolism & Toxicology