Comparison of nucleoside concentrations in blood of fish with and without tumors
- Environmental Protection Agency, Duluth, MN (United States)
- Univ. of Wisconsin, Superior (United States)
- Univ. of Minnesota, Duluth (United States)
- Oregon State Univ., Corvallis (United States)
The objective of this study was to develop and use HPLC based analytical methodology to characterize nucleosides in blood plasma and serum from fish with and without tumors, with a goal of determining if fish blood nucleoside concentrations could similarly be used as a bioindicator of tumor development in fish. The approach was to develop analytical methodology and quality assurance criteria for the analysis of nucleosides in fish blood, and to characterize nucleoside concentrations in blood of fish for which both healthy and tumor-bearing samples were available. Data would then be used to establish parameters with which tumor-bearing fish could be distinguished from healthy fish. Blood samples used to establish the diagnostic parameters were from control rainbow trout (Oncorhynchus mykiss) and those with tumors developed after exposure to aflatoxins. A second set of blood samples was from field collected black bullheads (Ictalurus melas).
- OSTI ID:
- 7235860
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology; (United States), Vol. 46:5; ISSN 0007-4861
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
AFLATOXINS
BIOLOGICAL EFFECTS
NUCLEOSIDES
CHEMICAL ANALYSIS
WATER POLLUTION
BIOLOGICAL INDICATORS
QUANTITY RATIO
TROUT
ANIMALS
ANTIGENS
AQUATIC ORGANISMS
FISHES
HAZARDOUS MATERIALS
MATERIALS
NUCLEOTIDES
ORGANIC COMPOUNDS
POLLUTION
RIBOSIDES
TOXIC MATERIALS
TOXINS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology