Effects of meso-2,3-dimercaptosuccinic acid (DMSA) on the teratogenicity of sodium arsenate in mice

Journal Article · Fri Nov 01 00:00:00 EST 1991 · Bulletin of Environmental Contamination and Toxicology; (United States)

DOI:https://doi.org/10.1007/BF01701134· OSTI ID:7235822

Bosque, M A; Domingo, J L; Llobet, J M ^[1]; Corbella, J ^[2]

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1. Univ. of Barcelona, Reus (Spain)
2. Univ. of Barcelona (Spain)

Although the effects of arsenic on mammalian development are now well established, very few data on the protective activity of different chelators against embryotoxicity and teratogenicity of arsenic are available. Chelating agents may interact with teratogen metals to augment or ameliorate their actions. Researchers demonstrated that a single dose of 2,3-dimercaptopropanol (BAL) was capable of affording a degree of protection to arsenate exposed fetal mice. Subcutaneous treatment with 50 mg/kg of BAL 4 hr after arsenate reduced the frequency or severity of malformations compared with the effects of arsenate alone. However, BAL has several drawbacks. In recent years dimercaptosuccinic acid (DMSA) is receiving growing attention in the USA and Western Europe. Results of a number of different investigations in rodents have led to the conclusion that DMSA is much less toxic than BAL. Moreover, DMSA has been reported to be effective in inducing arsenic excretion. In the present study, the protective effects of DMSA in alleviating the embryotoxic and teratogenic effects of sodium arsenate were evaluated in mice.

• OSTI ID: 7235822
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (United States), Vol. 47:5; ISSN 0007-4861
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ARSENATES
TOXICITY
CHELATING AGENTS
BIOLOGICAL EFFECTS
MICE
SODIUM COMPOUNDS
SUCCINIC ACID
TERATOGENESIS
ALKALI METAL COMPOUNDS
ANIMALS
ARSENIC COMPOUNDS
CARBOXYLIC ACIDS
DICARBOXYLIC ACIDS
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology