Marrow granulomas in coal workers' pneumoconiosis. A histologic study with elemental analysis
The differential diagnosis of bone marrow granulomas is lengthy but has not previously included coal workers' pneumoconiosis. This report describes the first case in which noncaseating epithelioid granulomas containing anthracotic pigment and birefringent silica containing crystals were discovered in the marrow of a patient with progressive massive fibrosis of coal workers' pneumoconiosis. The silicotic nature of the crystals was confirmed using energy dispersive x-ray microanalysis. There was no evidence of a mycobacterial, fungal, or other etiology for the granulomas. This case demonstrates that coal workers' pneumoconiosis should be added to the differential diagnosis of bone marrow granulomas and that marrow examination may be a source of tissue for documentation of specific occupational exposures.
- Research Organization:
- Univ. of Cincinnati College of Medicine, OH (USA)
- OSTI ID:
- 7229988
- Journal Information:
- Am. J. Clin. Pathol.; (United States), Vol. 89:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
BONE MARROW
GRANULOMAS
COAL
TOXICITY
ETIOLOGY
COAL MINERS
ELECTRON MICROPROBE ANALYSIS
OCCUPATIONAL EXPOSURE
PNEUMOCONIOSES
SILICA
ANIMAL TISSUES
BODY
CARBONACEOUS MATERIALS
CHALCOGENIDES
CHEMICAL ANALYSIS
DISEASES
ENERGY SOURCES
FOSSIL FUELS
FUELS
HEMATOPOIETIC SYSTEM
MATERIALS
MICROANALYSIS
MINERALS
MINERS
NEOPLASMS
ORGANS
OXIDE MINERALS
OXIDES
OXYGEN COMPOUNDS
PERSONNEL
RESPIRATORY SYSTEM DISEASES
SILICON COMPOUNDS
SILICON OXIDES
TISSUES
016000* - Coal
Lignite
& Peat- Health & Safety
560300 - Chemicals Metabolism & Toxicology
550901 - Pathology- Tracer Techniques