Increase of urinary and serum hydroxyproline in subjects exposed to cadmium

Journal Article · Tue Oct 01 00:00:00 EDT 1991 · Bulletin of Environmental Contamination and Toxicology; (United States)

DOI:https://doi.org/10.1007/BF01700953· OSTI ID:7206307

Nishino, H; Tanaka, T; Shiroishi, K; Sato, S ^[1]; Naruse, Y; Kagamimori, S ^[2]

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1. Toyama Inst. of Health (Japan)
2. Toyama Medical and Pharmaceutical Univ. (Japan)

Itai-itai disease (I disease) is characterized mainly by renal tubular damage and osteomalacia accompanied by osteoporosis in subjects with long-term ingestion of excessive cadmium (Cd). Most of the studies on the osteopathies of this disease have focused on mineral metabolism. For a better understanding of the osteopathies of I disease, the authors have been interested in collagen metabolism in relation to that of minerals. It is possible that the increased urinary concentration of Hyp may be associated with the osteopathies of patients with I disease. To provide more information about the increased urinary concentration resulting from Cd exposure the measurement of serum concentration of Hyp was also carried out in the present study.

• OSTI ID: 7206307
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (United States), Vol. 47:4; ISSN 0007-4861
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BLOOD SERUM
CHEMICAL ANALYSIS
CADMIUM COMPOUNDS
BIOLOGICAL ACCUMULATION
URINE
EXCRETION
JAPAN
WOMEN
ANIMALS
ASIA
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CLEARANCE
DEVELOPED COUNTRIES
FEMALES
MAMMALS
MAN
MATERIALS
PRIMATES
VERTEBRATES
WASTES
560300* - Chemicals Metabolism & Toxicology