The polymorphic ADP-ribosyltransferase (NAD[sup +]) pseudogene 1 in humans interrupts an endogenous pol-like element on 13q34

Journal Article · Mon Nov 01 00:00:00 EST 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1456· OSTI ID:7200415

Lyn, D; Istock, N L; Smulson, M ^[1]; Deaven, L L ^[2]

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1. Georgetown Univ. School of Medicine, Washington, DC (United States)
2. Los Alamos National Lab., NM (United States)

A recently constructed chromosome 13-enriched library was used to isolate the entire human ADP-ribosyltransferase (NAD[sup +]) pseudogene 1 gene (ADPRTP1) on 13q34. Recently, ADPRTP1 was shown to detect a restriction fragment length polymorphism that was associated with a predisposition to cancer. The complete sequence of the ADPRTP1 (3808 bases) was determined and found to resemble an intronless cDNA, including 137 bases of the 5[prime] untranslated region and a short poly(A) tail. A previously uncharacterized, endogenous pol-like element (1.53 kb) in which the DNA sequences were interrupted by the polymorphic ADPRTP1 was identified. The solitary pol-related retroviral element may represent a multimember family of viral-like DNA sequences dispersed throughout the human genome. Altogether a 9.25-kb genomic region that also encompassed two Alu elements and the long-terminal repeat-like element of the [open quotes]O[close quotes]-LTR family was characterized. 27 refs., 4 figs., 1 tab.

• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 7200415
• Journal Information: Genomics; (United States), Vol. 18:2; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GENES
DNA SEQUENCING
HUMAN CHROMOSOME 13
GENETIC MAPPING
PENTOSYL TRANSFERASES
DNA-CLONING
NEOPLASMS
RFLPS
CHROMOSOMES
CLONING
DISEASES
DNA HYBRIDIZATION
ENZYMES
GLYCOSYL TRANSFERASES
HUMAN CHROMOSOMES
HYBRIDIZATION
MAPPING
ORGANIC COMPOUNDS
PROTEINS
STRUCTURAL CHEMICAL ANALYSIS
TRANSFERASES
550400* - Genetics