Genetic determination of high-density lipoprotein-cholesterol and apolipoprotein A-1 plasma levels in a family study of cardiac catheterization patients

Journal Article · Sun Nov 01 00:00:00 EST 1992 · American Journal of Human Genetics; (United States)

OSTI ID:7199614

Prenger, V L; Beaty, T H; Kwiterovich, P O ^[1]

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1. John Hopkins Univ., Baltimore, MD (United States)

Plasma levels of two lipoprotein risk factors, high-density lipoprotein-cholesterol (HDL-C) and apolipoprotein A-1 (apo A-1), have been shown to be negatively associated with the risk of developing coronary artery disease, and several reports have examined familial factors in HDL-C and apo A-1 levels. A number of studies suggest that shared genes influence familial resemblance of these lipoprotein levels far more than do shared environments. Possible mechanisms for the inheritance of these risk factors (HDL-C and apo A-1 plasma levels) are explored using data from 390 individuals in 69 families ascertained through probands undergoing diagnostic cardiac catheterization. Segregation analysis was used to test a series of specific models of inheritance. Evidence for single-locus control of apo A-1 levels, with Mendelian transmission of a dominant allele leading to elevated apo A-1 levels, was seen in these families, although there was additional correlation among sibs present. This locus accounted for 48.6% and 37.2% of the total variation in apo A-1 levels in males and females, respectively. Similar evidence of segregation at a single locus controlling HDL-C levels was not seen in these families. 27 refs., 3 figs., 5 tabs.

• OSTI ID: 7199614
• Journal Information: American Journal of Human Genetics; (United States), Vol. 51:5; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
APOLIPOPROTEINS
CONCENTRATION RATIO
BLOOD PLASMA
CHEMICAL COMPOSITION
CARDIOVASCULAR DISEASES
GENETICS
CHOLESTEROL
LIPOPROTEINS
BIOLOGICAL MATERIALS
BIOLOGY
BLOOD
BODY FLUIDS
DISEASES
HYDROXY COMPOUNDS
LIPIDS
MATERIALS
ORGANIC COMPOUNDS
PROTEINS
STEROIDS
STEROLS
550400* - Genetics
550900 - Pathology