Rapid method for isolating targeted organic chemicals from biological matrices
Journal Article
·
· Analytical Letters; (United States)
- Oak Ridge National Lab., TN (United States)
- Univ. of Iowa, Iowa City, IA (United States)
The initial development is reported for a novel countercurrent filtration/dialysis and solid phase extractant system for the rapid isolation of low molecular weight target compounds from biological media. Except for piperazine (a highly water-soluble drug), recoveries of 50 - 95% were achieved for chemical warfare agent simulants and anthelmintic drugs extracted from meat, grain, or milk. The results suggest the potential for broad applications to complex samples such as environmental media and physiological specimens which traditionally require extensive fractionation prior to analysis.
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 7197821
- Journal Information:
- Analytical Letters; (United States), Vol. 27:2; ISSN 0003-2719
- Country of Publication:
- United States
- Language:
- English
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