Isocyanates and respiratory disease: current status

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Am. J. Ind. Med.; (United States)

DOI:https://doi.org/10.1002/ajim.4700130304· OSTI ID:7194715

Musk, A W; Peters, J M; Wegman, D H

This paper reviews the known respiratory effects of isocyanates. There is good evidence to indicate that isocyanates: cause chemical bronchitis/pneumonitis; are potent pulmonary sensitizers capable of causing isocyanate asthma; cause nonspecific airways disease, including chronic bronchitis; can induce a general asthmatic state; and can cause hypersensitivity pneumonitis. Similar dose-response relationships are seen for both acute and chronic effects. There are plants operating in which exposures are well controlled and in which no respiratory effects can be detected. Suggestions are provided for preplacement assessment and periodic surveillance for workers exposed to these compounds.114 references.

• Research Organization: Sir Charles Gairdner Hospital, Nedlands (Australia)
• OSTI ID: 7194715
• Journal Information: Am. J. Ind. Med.; (United States), Vol. 13:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CYANATES
TOXICITY
AIR POLLUTION
DOSE-RESPONSE RELATIONSHIPS
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
PERSONNEL
RESPIRATORY SYSTEM DISEASES
REVIEWS
CARBONIC ACID DERIVATIVES
DISEASES
DOCUMENT TYPES
NITROGEN COMPOUNDS
ORGANIC COMPOUNDS
POLLUTION
560300* - Chemicals Metabolism & Toxicology