Transforming genes in chronic myelogenous leukemia

Journal Article · Tue Mar 01 00:00:00 EST 1988 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.85.6.1952· OSTI ID:7193263

Liu, E; Hjelle, B; Bishop, J M ^[1]

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1. Univ. of California, San Francisco (USA)

Chronic myelogenous leukemia (CML) is a hematopoietic malignancy characterized by an indolent chronic phase that invariably leads to a blast crisis indistinguishable from acute leukemia. Using a sensitive assay based on gene transfer and tumorigenesis, the authors sought evidence that damage to protooncogenes might figure in the progression from the chronic to the blast phase of CML. Seven of the 12 patients with CML examined in this manner harbored transforming genes. Mutations in RAS protooncogenes were detected in the leukemic cells from 1 or 6 chronic-phase patients, and 3 of 6 blast-crisis patients. In addition, a presently unidentified transforming gene (neither RAS nor RAF) was detected in 1 patient with chronic phase and 1 with blast crisis. These data indicate that mutations in RAS genes may play diverse roles in the pathogenesis of CML.

• OSTI ID: 7193263
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 85:6; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DNA
AUTORADIOGRAPHY
LEUKEMIA
GENETICS
ONCOGENES
DNA-CLONING
CARCINOGENESIS
CODONS
GENE MUTATIONS
HYBRIDIZATION
MICE
PATIENTS
PHILADELPHIA CHROMOSOME
ANIMALS
BIOLOGY
CHROMOSOMES
CLONING
DISEASES
DNA HYBRIDIZATION
GENES
HEMIC DISEASES
IMMUNE SYSTEM DISEASES
MAMMALS
MUTATIONS
NEOPLASMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PATHOGENESIS
RODENTS
VERTEBRATES
550401* - Genetics- Tracer Techniques