Leukotriene C4 elimination and metabolism in man
Journal Article
·
· Journal of Allergy and Clinical Immunology; (USA)
- Royal Postgraduate Medical School, London (England)
Three doses of radiolabeled leukotriene C4 (0.2 to 15 muCi) were infused into three subjects to investigate its metabolism and routes of elimination during 4 days. Between 12% and 20% of the infused dose was recovered in the urine within 24 hours, of which a substantial and relatively constant proportion (4.1% to 6.3% total dose) appeared as leukotriene E4 (LTE4), mainly in the first 4 hours. Polar omega-oxidation products, N-acetyl LTE4, and tritiated water were also present. Fecal elimination accounted for a further 30% to 40% of the infused dose. In the absence of altered metabolism or biliary excretion, urinary LTE4 may be a useful measure of whole body production of the cysteinyl leukotrienes.
- OSTI ID:
- 7191494
- Journal Information:
- Journal of Allergy and Clinical Immunology; (USA), Vol. 85; ISSN 0091-6749
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
PROSTAGLANDINS
METABOLISM
DOSE-RESPONSE RELATIONSHIPS
FECES
MAN
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
MAMMALS
MATERIALS
PRIMATES
VERTEBRATES
WASTES
550501* - Metabolism- Tracer Techniques
PROSTAGLANDINS
METABOLISM
DOSE-RESPONSE RELATIONSHIPS
FECES
MAN
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
MAMMALS
MATERIALS
PRIMATES
VERTEBRATES
WASTES
550501* - Metabolism- Tracer Techniques