Ultraviolet irradiation in transplantation biology. Manipulation of immunity and immunogenicity

Journal Article · Sun May 01 00:00:00 EDT 1988 · Transplantation; (United States)

OSTI ID:7189961

Deeg, H J

Ultraviolet irradiation, particularly in the UVB range, has profound effects on immunological mechanisms. Optimum and tolerable doses of exposure vary from species to species, and from organ to organ. As a result of limited depth penetration and possibly significant energy absorption in nontargeted cells, every model requires diligent determination of an effective nontoxic approach. Nevertheless, it is clear that UVB and UVC irradiation can abolish proliferative and stimulatory ability as well as accessory/antigen-presenting ability of leukocytes in vitro. UV treatment alters cell-surface properties, calcium mobilization, cytokine production and release, and other subcellular processes. Preliminary data suggest that these manipulations also suppress immunity and reduce immunogenicity in vivo. Exposure of solid organs and of large volumes of blood is difficult due to technical problems--in particular poor depth penetration and absorption of UV energy in generally available transfusion bags. 111 references.

• Research Organization: Georgetown Univ., Washington, DC (USA)
• OSTI ID: 7189961
• Journal Information: Transplantation; (United States), Vol. 45:5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
IMMUNITY
RADIOINDUCTION
LYMPHOCYTES
CELL PROLIFERATION
ORGANS
TRANSPLANTS
REVIEWS
SKIN
ULTRAVIOLET RADIATION
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DOCUMENT TYPES
ELECTROMAGNETIC RADIATION
LEUKOCYTES
MATERIALS
RADIATIONS
SOMATIC CELLS
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture