Involvement of prostaglandins and histamine in radiation-induced temperature responses in rats
- Armed Forces Radiobiology Research Institute, Bethesda, MD (USA)
Exposure of rats to 1-15 Gy of gamma radiation induced hyperthermia, whereas exposure to 20-150 Gy produced hypothermia. Since radiation exposure induced the release of prostaglandins (PGs) and histamine, the role of PGs and histamine in radiation-induced temperature changes was examined. Radiation-induced hyper- and hypothermia were antagonized by pretreatment with indomethacin, a cyclooxygenase inhibitor. Intracerebroventricular administration of PGE2 and PGD2 induced hyper- and hypothermia, respectively. Administration of SC-19220, a specific PGE2 antagonist, attenuated PGE2- and radiation-induced hyperthermia, but it did not antagonize PGD2- or radiation-induced hypothermia. Consistent with an apparent role of histamine in hypothermia, administration of disodium cromoglycate (a mast cell stabilizer), mepyramine (H1-receptor antagonist), or cimetidine (H2-receptor antagonist) attenuated PGD2- and radiation-induced hypothermia. These results suggest that radiation-induced hyperthermia is mediated via PGE2 and that radiation-induced hypothermia is mediated by another PG, possibly PGD2, via histamine.
- OSTI ID:
- 7189767
- Journal Information:
- Radiation Research; (USA), Vol. 121:1; ISSN 0033-7587
- Country of Publication:
- United States
- Language:
- English
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Implication of prostaglandins and histamine H1 and H2 receptors in radiation-induced temperature responses of rats
Implication of prostaglandins and histamine H1 and H2 receptors in radiation-induced temperature responses of rats
Related Subjects
HISTAMINE
RADIOSENSITIVITY EFFECTS
HYPERTHERMIA
RADIOINDUCTION
PROSTAGLANDINS
BODY TEMPERATURE
GAMMA RADIATION
RATS
AMINES
ANIMALS
AZOLES
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals