Direct enhancement by cigarette smoke of asbestos fiber penetration and asbestos-induced epithelial proliferation in rat tracheal explants

Journal Article · Wed Jun 01 00:00:00 EDT 1988 · JNCI, J. Natl. Cancer Inst.; (United States)

DOI:https://doi.org/10.1093/jnci/80.7.518· OSTI ID:7189297

Hobson, J; Gilks, B; Wright, J; Churg, A

Tracheal explants from Sprague-Dawley rats were briefly exposed to cigarette smoke or air (control) and then to amosite asbestos. Asbestos fibers in or under the tracheal epithelium were counted and extent of hyperplastic lesions was ascertained at 24 hours, 72 hours, and 1 week after exposure. Smoke-exposed cultures showed significantly greater numbers of fibers in the epithelium and greater proliferative activity compared to findings in cultures not exposed to smoke. These observations indicate that very short exposure to cigarette smoke can directly affect the response of the epithelium to asbestos fibers and that smoke exposure need not be concurrent with asbestos exposure for such event to occur. These reactions may play a role in the greater incidences of lung cancer and asbestosis seen in asbestos-exposed workers who smoke.

• Research Organization: Univ. of British Columbia, Vancouver (Canada)
• OSTI ID: 7189297
• Journal Information: JNCI, J. Natl. Cancer Inst.; (United States), Vol. 80:7
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ASBESTOS
TOXICITY
EPITHELIUM
PERMEABILITY
TOBACCO SMOKES
BIOLOGICAL EFFECTS
CELL DIVISION
RATS
TRACHEA
TRANSPLANTS
AEROSOLS
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RESPIRATORY SYSTEM
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