Aneuploidy induction in Saccharomyces cerevisiae by two solvent compounds, 1-methyl-2-pyrrolidinone and 2-pyrrolidinone

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Environ. Mol. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2850110105· OSTI ID:7189119

Mayer, V M; Goin, C J; Taylor-Mayer, R E

A number of solvent compounds, that were tested in Saccharomyces cerevisiae were potent inducers of aneupolidy, although they did not induce any other genetic effects. As an extention of these earlier findings, 1-methyl-2-pyrrolidinone was tested and was found to induce aneuploidy. Several structurally related compounds were also tested; 2-pyrrolidinone induced aneuploidy, but succinimide, pyrrolidine, 1-methylpyrrolidine, 1-methyl-3-pyrrolidinol, and 2-pyrrolidineethanol did not. Maleimide and its N-hydroxy, N-methyl, and N-ethyl derivatives were also negative for aneuploidy induction.

• Research Organization: Food and Drug Administration, Washington, DC (USA)
• OSTI ID: 7189119
• Journal Information: Environ. Mol. Mutagen.; (United States), Vol. 11:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
PYRROLIDONES
DERIVATIZATION
GENETIC EFFECTS
SACCHAROMYCES CEREVISIAE
ANEUPLOIDY
MUTAGEN SCREENING
ORGANIC SOLVENTS
AMIDES
AZOLES
BIOLOGICAL EFFECTS
CHEMICAL REACTIONS
FUNGI
HETEROCYCLIC COMPOUNDS
LACTAMS
MICROORGANISMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PLANTS
PLOIDY
PYRROLES
SACCHAROMYCES
SCREENING
SOLVENTS
YEASTS
560300* - Chemicals Metabolism & Toxicology