Absence of missense mutations in activated c-myc genes in avian leukosis virus-induced B-cell lymphomas
Journal Article
·
· Mol. Cell. Biol.; (United States)
The authors determined the nucleotide sequences of two independent DNA clones which contained the activated c-myc genes from avian leukosis virus-induced B-cell lymphomas. Neither of these c-myce genes contained missense mutations. This strongly supports the notion that the c-myc photo-oncogene in avian leukosis virus-induced B-cell lymphomas can be oncogenically activated by altered expression of the gene without a change in the primary structure of the gene product.
- Research Organization:
- Graduate Program in Molecular Biology, Sloan-Kettering Institute for Cancer Research, and Cornell Univ. Graduate School of Medical Sciences, 1275 York Avenue, New York, NY (US)
- OSTI ID:
- 7188585
- Journal Information:
- Mol. Cell. Biol.; (United States), Vol. 8:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
GENE RECOMBINATION PROTEINS
MOLECULAR STRUCTURE
LEUKEMIA VIRUSES
MOLECULAR BIOLOGY
ONCOGENES
DNA SEQUENCING
BIRDS
DNA-CLONING
GENE MUTATIONS
LYMPHOMAS
NUCLEOPROTEINS
PHENOTYPE
ANIMALS
CLONING
DISEASES
GENES
IMMUNE SYSTEM DISEASES
MICROORGANISMS
MUTATIONS
NEOPLASMS
ONCOGENIC VIRUSES
ORGANIC COMPOUNDS
PARASITES
PROTEINS
STRUCTURAL CHEMICAL ANALYSIS
VERTEBRATES
VIRUSES
550200* - Biochemistry
550603 - Medicine- External Radiation in Therapy- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
GENE RECOMBINATION PROTEINS
MOLECULAR STRUCTURE
LEUKEMIA VIRUSES
MOLECULAR BIOLOGY
ONCOGENES
DNA SEQUENCING
BIRDS
DNA-CLONING
GENE MUTATIONS
LYMPHOMAS
NUCLEOPROTEINS
PHENOTYPE
ANIMALS
CLONING
DISEASES
GENES
IMMUNE SYSTEM DISEASES
MICROORGANISMS
MUTATIONS
NEOPLASMS
ONCOGENIC VIRUSES
ORGANIC COMPOUNDS
PARASITES
PROTEINS
STRUCTURAL CHEMICAL ANALYSIS
VERTEBRATES
VIRUSES
550200* - Biochemistry
550603 - Medicine- External Radiation in Therapy- (1980-)