Cell proliferation in mouse tissues after thymectomy and t-activin administration
Cell proliferation was studied in mouse tissues on a model of immunodeficiency, namely at different times after splenectomy, and also after immunocorrection with the thymus preparation T-Activin, which is known to restore many functions of the T system of immunity. Mice either received thymectomy, mock thymectomy, or were injected with T-Activin. Tritium-thymidine was injected before the mice were killed. The results of investigation of mitotic activity during the 24-h period in the corneal epithelium 9 days after thymectomy are presented. Thymectomy performed on adult animals leads to a decrease in the intensity of cell proliferation in the epithelial tissues and to a disturbance of the rhythm of proliferation soon after the operation. The experiments show that a lyphocyte function such as the regulation of proliferation remains sensitive to T-Activin, an immunoactive factor of the thymus.
- Research Organization:
- N.I. Pirogov Second Moscow Medical Institute
- OSTI ID:
- 7188402
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 99:1
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effects of tritium-labeled pyrimidine nucleosides on epithelial cell proliferation in the mouse. I. Cytodynamic perturbations in normal circadian rhythms after a single injection of /sup 3/H-thymidine
Kinetics of corneal epithelium turnover in vivo. Studies of lovastatin
Related Subjects
EPITHELIUM
CELL PROLIFERATION
RADIOIMMUNOASSAY
LYMPHOCYTES
MICE
THYMECTOMY
MITOGENS
BIOLOGICAL EFFECTS
BIOCHEMICAL REACTION KINETICS
BIOSYNTHESIS
CORNEA
DAILY VARIATIONS
DNA
MITOTIC INDEX
THYMIDINE
TRITIUM COMPOUNDS
UPTAKE
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AZINES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY AREAS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
EYES
FACE
HEAD
HETEROCYCLIC COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
LEUKOCYTES
MAMMALS
MATERIALS
MEDICINE
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RADIOASSAY
RADIOIMMUNOLOGY
REACTION KINETICS
RIBOSIDES
RODENTS
SENSE ORGANS
SOMATIC CELLS
SURGERY
SYNTHESIS
TISSUES
TRACER TECHNIQUES
VARIATIONS
VERTEBRATES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)