Uptake of indium-111-labeled monoclonal antibody ZME-018 as a function of tumor size in a patient with melanoma

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Am. J. Physiol. Imag.; (United States)

OSTI ID:7187162

Macey, D J; Denardo, S J; Denardo, G L; Goodnight, J K; Unger, M W

The accumulation of an Indium-111-labeled monoclonal antibody (MoAb), ZME-018, in melanoma tumors in a patient was determined by sequential, quantitative gamma camera imaging. The amount and concentration of In-111 in each tumor changed in a characteristic pattern with time, reaching a peak at day 3 followed by a steady clearance. The concentration of In-111 in the tumor and the ratios of tumor to whole-body or blood decreased as the size of the tumor increased. These results were interpreted to indicate that the fraction of active, perfused tumor decreased as the melanoma lesions increased in size. The maximum number of MoAb molecules bound per melanoma cell was calculated to be abut 35,000. The implications of these observations for radioimmunoimaging and therapy are significant.

• Research Organization: Univ. of California Davis Medical Center, Sacramento (USA)
• OSTI ID: 7187162
• Journal Information: Am. J. Physiol. Imag.; (United States), Vol. 3:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
INDIUM 111
UPTAKE
MELANOMAS
DIAGNOSIS
MONOCLONAL ANTIBODIES
DIAGNOSTIC USES
BIOLOGICAL LOCALIZATION
GAMMA CAMERAS
PATIENTS
RADIOIMMUNOSCINTIGRAPHY
ANTIBODIES
BETA DECAY RADIOISOTOPES
CAMERAS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics