Cytogenetic evaluation of chromosomal disorders in Down Syndrome
Down Syndrome (DS) patients are at high risk to develop leukemia. They are also highly sensitive to the induction of chromosomal aberrations when their GO lymphocytes are irradiated in vitro. The objective of this study was to further investigate the differential radiosensitivity of DS lymphocytes at the different stages of the cell cycle, as damage to proliferating cells is more relevant to health problems than damage to non-dividing cells. In addition, the proliferation kinetics and stage of differentiation of circulating DS lymphocytes was studied in an attempt to understand the mechanism for the enhanced chromosomal radiosensitivity. Moreover, the x-ray induced specific chromosomal breakpoints were identified and correlated with the locations of oncogene and fragile sites in order to investigate cytogenetically the early stages of leukemogenesis.
- Research Organization:
- Texas Univ., Galveston (USA)
- OSTI ID:
- 7184779
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CHROMOSOMAL ABERRATIONS
RADIOINDUCTION
DOWNS SYNDROME
PATHOGENESIS
LYMPHOCYTES
CELL PROLIFERATION
RADIOSENSITIVITY
CELL CYCLE
LEUKEMIA
ONCOGENIC TRANSFORMATIONS
PATIENTS
X RADIATION
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL TRANSFORMATIONS
CONGENITAL MALFORMATIONS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
HEMIC DISEASES
HEREDITARY DISEASES
IMMUNE SYSTEM DISEASES
IONIZING RADIATIONS
LEUKOCYTES
MALFORMATIONS
MATERIALS
MUTATIONS
NEOPLASMS
PATHOLOGICAL CHANGES
RADIATIONS
SOMATIC CELLS
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture
550900 - Pathology