Effects of laser irradiation on immature olfactory neuroepithelial explants from the rat
The photobiological effect of low-output laser irradiation on the maturation and regeneration of immature olfactory bipolar receptor cells of the rat was studied. The maturation and regeneration of the receptor cells of rat fetuses were quantified in neuroepithelial explants with morphometric analysis. The number of explants with outgrowth and the number and length of neuritic outgrowths were determined on a regular basis for 12 days. Explants in the experimental group were irradiated with a helium-neon laser using different incident energy densities (IED). Explants in the fluorescent light control group were exposed to fluorescent light for the same periods of time as those in the experimental group were exposed to laser irradiation. Explants in another control group were not exposed to laser or fluorescent light irradiation. The IED of 0.5 J/cm2 laser irradiation has been found to increase significantly the number of explants with outgrowth and the number and length of the outgrowths. Other laser IEDs or fluorescent light irradiation did not influence maturation or regeneration.
- Research Organization:
- Univ. of Pennsylvania Medical Center, Philadelphia (USA)
- OSTI ID:
- 7183536
- Journal Information:
- Laryngoscope; (United States), Vol. 98:7
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
EPITHELIUM
TRANSPLANTS
LASER RADIATION
BIOLOGICAL EFFECTS
NERVES
BIOLOGICAL REGENERATION
FETUSES
FLUORESCENT LAMPS
HELIUM-NEON LASERS
IN VITRO
OLFACTORY BULBS
RATS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL RECOVERY
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
ELECTROMAGNETIC RADIATION
GAS LASERS
LASERS
LIGHT BULBS
MAMMALS
NERVOUS SYSTEM
ORGANS
RADIATIONS
RECOVERY
RODENTS
TISSUES
VERTEBRATES
560400* - Other Environmental Pollutant Effects