Synthesis of 1,4,5,6-tetrahydropyridine derivatives starting from trans-3-chloro-1,3-alkadien-5-ones
A method has been developed for the synthesis of 3-carbethoxy-2-methyl-6-(oxo-alkylidene)-1,4,5,6-tetrahydropyridines by reaction of trans-3-chloro-1,3-alkadien-5-ones with ethyl aminocrotonate. It is shown that the corresponding vinylacetylanic ketones are intermediate products of the reactions. PMR spectra in CCl/sub 4/ were obtained on a Perkin-Elmer R12B (60 MHz) spectrometer, with TMS as internal standard. /sup 13/C NMR spectra were recordeed on a Bruker WH-90 instrument (22.63 MHz) without suppression and with complete suppression of spin-spin coupling. IR spectra were recorded in CCl/sub 4/ on a UR-10 instrument, mass spectra were recorded on a MX-1303 spectrometer with electron ionization energy of 30 eV.
- Research Organization:
- Institute of Organic Chemistry, Erevan (USSR)
- OSTI ID:
- 7169337
- Journal Information:
- Chem. Heterocycl. Compd. (Engl. Transl.); (United States), Vol. 23:4; Other Information: Translated from Khim. Geterotsikl. Soedin.; 23: No. 4, 497-500(Apr 1987)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
74 ATOMIC AND MOLECULAR PHYSICS
PYRIDINES
MASS SPECTRA
NMR SPECTRA
SYNTHESIS
CARBON 13
CARBOXYLIC ACID ESTERS
CHEMICAL SHIFT
CHLOROFORM
COUPLING CONSTANTS
CROTONIC ACID
DEUTERIUM COMPOUNDS
DIENES
INFRARED SPECTRA
IONIZATION
J-J COUPLING
KETONES
MULTIPLETS
ORGANIC CHLORINE COMPOUNDS
REACTION INTERMEDIATES
STRUCTURAL CHEMICAL ANALYSIS
VINYL MONOMERS
AZINES
CARBON ISOTOPES
CARBOXYLIC ACIDS
CHLORINATED ALIPHATIC HYDROCARBONS
COUPLING
ESTERS
EVEN-ODD NUCLEI
HALOGENATED ALIPHATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
HYDROGEN COMPOUNDS
INTERMEDIATE COUPLING
ISOTOPES
LIGHT NUCLEI
MONOCARBOXYLIC ACIDS
MONOMERS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
POLYENES
SPECTRA
STABLE ISOTOPES
400201* - Chemical & Physicochemical Properties
640302 - Atomic
Molecular & Chemical Physics- Atomic & Molecular Properties & Theory