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Title: Induction of hepatic cytochrome P-450 activity in wild cotton rats (Sigmodon hispidus) by phenobarbital and 3-methylcholanthrene

Abstract

Wild cotton rats (Sigmodon hispidus) are ubiquitous throughout the Southeast quadrant of the United States, easy to capture, have a generation interval of less than one year and a limited range of movement (less than one hectare). This species may prove to be an excellent model for monitoring environmental contamination. Traditionally, cytochrome P-450 inducing agents are grouped into two classes. One, represented by phenobarbital, induces P-450b and P-450e; the other, represented by 3-methylcholanthrene, induces P-450c and P-450d isoenzymes. The types and amounts of cytochrome P-450 vary among species, organs, health status, sex, and stress of the animal. If the levels of cytochrome P-450 of wild cotton rats are to be used in monitoring environmental pollution, it is necessary to characterize the inducibility and concentration of cytochrome P-450 in this species. This study was designed to determine the concentration and inducibility of cytochrome P-450 in the livers of cotton rats after intraperitoneal (ip) administration of phenobarbital and 3-methylcholanthrene.

Authors:
; ;  [1]
  1. Oklahoma State Univ., Stillwater (USA)
Publication Date:
OSTI Identifier:
7167234
Resource Type:
Journal Article
Journal Name:
Bulletin of Environmental Contamination and Toxicology; (USA)
Additional Journal Information:
Journal Volume: 42:5; Journal ID: ISSN 0007-4861
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 3-METHYLCHOLANTHRENE; BIOLOGICAL EFFECTS; CYTOCHROMES; ENZYME INDUCTION; PHENOBARBITAL; BIOCHEMISTRY; ENZYME ACTIVITY; INTRAPERITONEAL INJECTION; LIVER; PREGNANCY; RATS; SEX DEPENDENCE; ANESTHETICS; ANIMALS; ANTICONVULSANTS; AROMATICS; AZINES; BARBITURATES; BODY; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CHEMISTRY; DIGESTIVE SYSTEM; DRUGS; GENE REGULATION; GLANDS; HETEROCYCLIC COMPOUNDS; HYDROCARBONS; HYPNOTICS AND SEDATIVES; INJECTION; INTAKE; MAMMALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANS; PIGMENTS; POLYCYCLIC AROMATIC HYDROCARBONS; PROTEINS; PYRIMIDINES; RODENTS; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology

Citation Formats

Elangbam, C S, Qualls, Jr, C W, and Bauduy, M. Induction of hepatic cytochrome P-450 activity in wild cotton rats (Sigmodon hispidus) by phenobarbital and 3-methylcholanthrene. United States: N. p., 1989. Web. doi:10.1007/BF01700393.
Elangbam, C S, Qualls, Jr, C W, & Bauduy, M. Induction of hepatic cytochrome P-450 activity in wild cotton rats (Sigmodon hispidus) by phenobarbital and 3-methylcholanthrene. United States. https://doi.org/10.1007/BF01700393
Elangbam, C S, Qualls, Jr, C W, and Bauduy, M. 1989. "Induction of hepatic cytochrome P-450 activity in wild cotton rats (Sigmodon hispidus) by phenobarbital and 3-methylcholanthrene". United States. https://doi.org/10.1007/BF01700393.
@article{osti_7167234,
title = {Induction of hepatic cytochrome P-450 activity in wild cotton rats (Sigmodon hispidus) by phenobarbital and 3-methylcholanthrene},
author = {Elangbam, C S and Qualls, Jr, C W and Bauduy, M},
abstractNote = {Wild cotton rats (Sigmodon hispidus) are ubiquitous throughout the Southeast quadrant of the United States, easy to capture, have a generation interval of less than one year and a limited range of movement (less than one hectare). This species may prove to be an excellent model for monitoring environmental contamination. Traditionally, cytochrome P-450 inducing agents are grouped into two classes. One, represented by phenobarbital, induces P-450b and P-450e; the other, represented by 3-methylcholanthrene, induces P-450c and P-450d isoenzymes. The types and amounts of cytochrome P-450 vary among species, organs, health status, sex, and stress of the animal. If the levels of cytochrome P-450 of wild cotton rats are to be used in monitoring environmental pollution, it is necessary to characterize the inducibility and concentration of cytochrome P-450 in this species. This study was designed to determine the concentration and inducibility of cytochrome P-450 in the livers of cotton rats after intraperitoneal (ip) administration of phenobarbital and 3-methylcholanthrene.},
doi = {10.1007/BF01700393},
url = {https://www.osti.gov/biblio/7167234}, journal = {Bulletin of Environmental Contamination and Toxicology; (USA)},
issn = {0007-4861},
number = ,
volume = 42:5,
place = {United States},
year = {Mon May 01 00:00:00 EDT 1989},
month = {Mon May 01 00:00:00 EDT 1989}
}