Characteristics of benzodiazepine receptors in rats differing in predisposition to experimental alcoholism

Journal Article · Sat Feb 01 00:00:00 EST 1986 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)

OSTI ID:7166196

Burov, Yu V; Maiskii, A I; Yukhananov, R Yu

This paper studies the number and affinity of benzodiazepine receptors for diazepam in the cerebral cortex and hippocampus of rats differently predisposed to the development of experimental alcoholism. Ethanol was injected once intraperitoneally, in a dose of 2.5 g/kg. Control animals received the same volume of physiological saline. Bound and free N-methyl-tritium-diazepam were separated by means of GF/B filters. The characteristics of benzodiazepine receptors are shown in rats differing in predisposition to the development of experimental alcoholism and in rats during voluntary chronic alcoholization. It is shown that weakening of functional acitivity of the GABA-benzodiazepam complex in animals predisposed to the development of experimental alcoholism is one of the neurochemical mechanisms of development of the abstinence syndrome.

• Research Organization: Academy of Medical Sciences of The USSR, Moscow
• OSTI ID: 7166196
• Journal Information: Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 100:9
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ETHANOL
BIOLOGICAL EFFECTS
PSYCHOTROPIC DRUGS
RADIORECEPTOR ASSAY
RATS
CEREBRAL CORTEX
CONDITIONED REFLEXES
HIPPOCAMPUS
BEHAVIOR
INTRAPERITONEAL INJECTION
RECEPTORS
RETENTION
TRITIUM COMPOUNDS
ALCOHOLS
ANIMALS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CEREBRUM
DRUGS
HYDROXY COMPOUNDS
INJECTION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PROTEINS
REFLEXES
RODENTS
TRACER TECHNIQUES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques
550101 - Behavioral Biology- Tracer Techniques