Blood supply to the brain and. beta. -endorphin and acth levels under the influence of thyrotrophin releasing hormone
The authors studied beta-endorphin because of its possible mediator role in terms of the cerebrovascular effects of thyrotrophin releasing hormone (TRH), and also because of data in the literature on antagonistic relations between TRH and the endogenous opioid system of the brain. Beta-endorphin was determined by radioimmunoassay; its level was determined after its separation from the beta-lipotrophin fraction. The investigation showed that TRH has a marked depressant effect on cerebrovascular vasoconstrictor refleces. Elevation of the blood ACTH level causes an increase in BP and in the tone of the cerebral vessels. An absence of correlation between the beta-endorphin and ACTH levels in the blood and CSF under the influence of TRH is shown.
- Research Organization:
- Institute of PharmaCology, Acad. of Medical Sci., Moscou
- OSTI ID:
- 7166159
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 99:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ACTH
RADIOIMMUNOASSAY
BLOOD VESSELS
CONTRACTION
BRAIN
BLOOD CIRCULATION
ENDORPHINS
TRH
BIOLOGICAL EFFECTS
BLOOD FLOW
CATS
CORRELATIONS
PEPTIDES
REFLEXES
RESPONSE MODIFYING FACTORS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
DRUGS
HORMONES
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
PROTEINS
RADIOASSAY
RADIOIMMUNOLOGY
TRACER TECHNIQUES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques