Correlation between number of type 2 serotonin receptors in the frontal cortex and intensity of serotonin-induced head jerks in mice

Journal Article · Sat Feb 01 00:00:00 EST 1986 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)

OSTI ID:7165951

Popova, N K; Kulikov, A V; Pak, D F

This paper shows interlinear differences discovered in the number of S2 receptors in the cerebral cortex and they are compared with the intensity of 5-HT-induced head jerking in mice of inbred lines. The number of S2 receptors was estimated from the quantity of tritium-spiperone, which is specifically bound by brain membrane preparations. Specific binding was assessed as the difference between the quantity of label bound in the absence and in the presence of methylsergide, a drug which specificably blocks S2 receptors. The presence of high correlation be= tween the number of S2 receptors and the number of head jerkings in mice reflects a genetic connection between this form of behavior and the serotonin system, and it in no way signifies that this phenomenon is controlled purely by the serotonin system and cannot be modulated by other mediator systems, for example, the adrenergic system.

• Research Organization: Russian Academy of Sciences (RAS), Novosibirsk (Russian Federation)
• OSTI ID: 7165951
• Journal Information: Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 100:9
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
MICE
BEHAVIOR
SEROTONIN
BIOLOGICAL EFFECTS
RADIORECEPTOR ASSAY
RECEPTORS
CEREBRAL CORTEX
CORRELATIONS
DOSE-RESPONSE RELATIONSHIPS
HEAD
INTRAPERITONEAL INJECTION
REFLEXES
RESPONSE FUNCTIONS
TRITIUM COMPOUNDS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BODY
BODY AREAS
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRUM
DRUGS
FUNCTIONS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
INJECTION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PROTEINS
PYRROLES
RADIOPROTECTIVE SUBSTANCES
RODENTS
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRYPTAMINES
VERTEBRATES
550501* - Metabolism- Tracer Techniques
550101 - Behavioral Biology- Tracer Techniques