Patterns of glycogen turnover in liver characterized by computer modeling
- Univ. of Southern California Medical School, Los Angeles (USA)
The authors used a computer model of liver glycogen turnover to reexamine the data of Devos and Hers, who reported the time course of accumulation in and loss from glycogen of label originating in (1-{sup 14}C)galactose injected at different times after the start of refeeding of 40-h fasted mice or rats. In the present study computer representation of individual glycogen molecules was utilized to account for growth and degradation of glycogen according to specific hypothetical patterns. Using this model they could predict the accumulation and localization within glycogen of labeled glucose residues and compare the predictions with the previously published data. They considered three specific hypotheses of glycogen accumulation during refeeding: (1) simultaneous, (2) sequential, and (3) accelerating growth. Hypothetical patterns of glycogen degradation were (1) ordered and (2) random degradation. The pattern of glycogen synthesis consistent with experimental data was a steadily increasing number of growing glycogen molecules, whereas during degradation glycogen molecules are exposed to degrading enzymes randomly, rather than in a specific reverse order of synthesis. These patterns predict the existence of a specific mechanism for the steadily increasing seeding of new glycogen molecules during synthesis.
- OSTI ID:
- 7165253
- Journal Information:
- American Journal of Physiology; (USA), Vol. 253:4; ISSN 0002-9513
- Country of Publication:
- United States
- Language:
- English
Similar Records
Fructose effect to enhance liver glycogen deposition is due to inhibition of glycogenolysis
Labeling of hepatic glycogen after short- and long-term stimulation of glycogen synthesis in rats injected with 3H-galactose
Related Subjects
CARBON 14 COMPOUNDS
BIOSYNTHESIS
GLYCOGEN
METABOLISM
MOLECULAR MODELS
COMPUTERIZED SIMULATION
GALACTOSE
LIVER
ALDEHYDES
BODY
CARBOHYDRATES
DIGESTIVE SYSTEM
GLANDS
HEXOSES
LABELLED COMPOUNDS
MATHEMATICAL MODELS
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
SACCHARIDES
SIMULATION
SYNTHESIS
550201* - Biochemistry- Tracer Techniques