Gastric injury induced by hemorrhage, local ischemia, and oxygen radical generation

Journal Article · Sat Aug 01 00:00:00 EDT 1987 · American Journal of Physiology; (USA)

OSTI ID:7164985

Wadhwa, S S; Perry, M A ^[1]

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1. Univ. of New South Wales, Kensington (Australia)

Gastric mucosal injury caused by local intra-arterial generation of oxygen-derived free radicals was compared with gastric injury caused by 30 min of hemorrhage-induced ischemia or local ischemia. The index of injury was the loss of {sup 51}Cr-labeled red cells across the gastric mucosa. Generation of oxygen radicals in the celiac artery caused a rapid increase in mucosal blood loss during the period of radical generation, and this loss was maintained after radical production ceased. Local ischemia produced similar mucosal injury; however, this occurred after reperfusion of the stomach and not during the ischemic episode. Hemorrhage-induced ischemia produced a threefold greater mucosal blood loss than local ischemia. The results of this study indicate that (1) oxygen radicals generated enzymatically in the blood supply to the stomach cause mucosal bleeding of similar magnitude to that observed after local ischemia and (2) that gastric ischemia induced by systemic hypotension produces more severe gastric injury than the same level of local hypotension.

• OSTI ID: 7164985
• Journal Information: American Journal of Physiology; (USA), Vol. 253:2; ISSN 0002-9513
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CHROMIUM 51
TRACER TECHNIQUES
ISCHEMIA
BIOLOGICAL EFFECTS
STOMACH
INJURIES
SUPEROXIDE RADICALS
ERYTHROCYTES
HEMORRHAGE
HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE
MUCOUS MEMBRANES
PERFUSED TISSUES
RATS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
CHROMIUM ISOTOPES
DIGESTIVE SYSTEM
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ENZYMES
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
GLYCOSYL TRANSFERASES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
MEMBRANES
NUCLEI
ORGANS
PATHOLOGICAL CHANGES
PENTOSYL TRANSFERASES
RADICALS
RADIOISOTOPES
RODENTS
SYMPTOMS
TISSUES
TRANSFERASES
VASCULAR DISEASES
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques