Prevention of the acute cytotoxicity associated with silica-containing minerals
The inventors have developed a method that may prevent the acute cytotoxicity of freshly fractured silica and silica containing minerals including asbestos and coal-mine dust containing silica. The method entails coating silica-containing minerals, including coal, with a monomolecular film of an aqueously compatible silane coupling agent, either during milling, processing or after grinding or fracturing of silica or silica-containing materials. The invention also provides for a method of preventing certain pulmonary diseases, have been considered as occupational hazards in certain professions, such as coal mining and any other profession where persons are subjected to the inhalation of small particles of freshly fractured or ground silica containing minerals.
- Research Organization:
- Department of Health and Human Services, Washington, DC (USA)
- Assignee:
- Department of Health and Human Services, Washington, DC.
- Patent Number(s):
- A US 7-429033
- OSTI ID:
- 7164613
- Resource Relation:
- Other Information: This Government-owned invention available for U.S. licensing and, possibly, for foreign licensing. Copy of application available NTIS
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
54 ENVIRONMENTAL SCIENCES
ASBESTOS
TOXICITY
COAL
DUSTS
PNEUMOCONIOSES
PREVENTIVE MEDICINE
SILICATE MINERALS
OCCUPATIONAL DISEASES
SILICON OXIDES
CARBONACEOUS MATERIALS
CHALCOGENIDES
DISEASES
ENERGY SOURCES
FOSSIL FUELS
FUELS
MATERIALS
MEDICINE
MINERALS
OXIDES
OXYGEN COMPOUNDS
RESPIRATORY SYSTEM DISEASES
SILICON COMPOUNDS
560300* - Chemicals Metabolism & Toxicology
540120 - Environment
Atmospheric- Chemicals Monitoring & Transport- (1990-)