Two-locus linkage analysis in multiple sclerosis (MS)
- National Public Health Institute, Helsinki (Finland) Univ. of Helsinki (Finland)
- Columbia Univ., New York (United States)
- Univ. of Helsinki (Finland)
- National Public Health Institute, Helsinki (Finland)
One of the major challenges in genetic linkage analyses is the study of complex diseases. The authors demonstrate here the use of two-locus linkage analysis in multiple sclerosis (MS), a multifactorial disease with a complex mode of inheritance. In a set of Finnish multiplex families, they have previously found evidence for linkage between MS susceptibility and two independent loci, the myelin basic protein gene (MBP) on chromosome 18 and the HLA complex on chromosome 6. This set of families provides a unique opportunity to perform linkage analysis conditional on two loci contributing to the disease. In the two-trait-locus/two-marker-locus analysis, the presence of another disease locus is parametrized and the analysis more appropriately treats information from the unaffected family member than single-disease-locus analysis. As exemplified here in MS, the two-locus analysis can be a powerful method for investigating susceptibility loci in complex traits, best suited for analysis of specific candidate genes, or for situations in which preliminary evidence for linkage already exists or is suggested. 41 refs., 6 tabs.
- OSTI ID:
- 7160109
- Journal Information:
- Genomics; (United States), Vol. 19:2; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
Similar Records
Linkage analyses of chromosome 6 loci, including HLA, in familial aggregations of Crohn disease
The existence of Usher syndrome type III proven by assignment of its locus to chromosome 3q by linkage